Description

Hericor – MRL

Benefits

Hericor – MRL Powder brings the best of both worlds, by putting together two powerful mushrooms: Hericium and Coriolus. This great combination can help with many disorders:

• Hericium was used for gastrointestinal protection against the proliferation of H. pylori and the development of ulcers.
• Coriolus is a natural source of antioxidants, therefore helping the body repair oxidative damage.
• With so many beta-glucans from both mushrooms, the body can react to pathogens much quicker avoiding disease or sickness.
• Supports the immune system by providing micronutrients and antimicrobial properties, therefore increasing the body’s defence mechanisms.

Ingredients

Hericor-MRL powder contains Organic Coriolus versicolor (50%) and Hericium erinaceus (50%) mushroom biomass, from mycelium and primordia (young fruit body) cultivated in Europe on a sterilized (autoclaved) substrate.

Suitable for Vegetarian, Vegan, Kosher, Halal, and Lactose Intolerant.

This product is hypoallergenic.

Recommended Dosage and Intake

Each bottle contains a 2g spoon. Take from 2g to 4g per day. All MRL products can be mixed with water, food, yogurt, or non-acid juice.

Above all: Do not exceed the recommended daily intake.

Warnings

If you are pregnant, breastfeeding, have a medical condition or are under medical supervision, please consult your professional healthcare before consumption.

It may not be suitable for children. Please check with your medical practitioner before consumption.

Food supplements should not be used as a substitute for a varied balanced diet and a healthy lifestyle.

Storage Instructions

Store in a cool, dry place, away from direct sunlight and heat.

Do not consume if the closure is broken.

Keep out of reach of children.

Recommended Clinical Articles

2015

• Trovato A, Siracusa R, Di Paola R, Scuto M, Fronte V, Koverech G, Luca M, Serra A, Toscano MA, Petralia A, Cuzzocrea S, Calabrese V. Redox modulation of cellular stress response and lipoxin A4 expression by Coriolus versicolor in rat brain: Relevance to Alzheimer’s disease pathogenesis. NeuroToxicology 2015;53:350–358. Doi: 1016/j.neuro.2015.09.012

2016

• Trovato A, Siracusa R,^#Di Paola R, Scuto M, Ontario ML, Bua O, Di Mauro P, Toscano MA, Petralia CCT, Maiolino L, SerraA, Cuzzocrea S, Calabrese Redox modulation of cellular stress response and lipoxin A4 expression by Hericium erinaceus in rat brain: Relevance to Alzheimer’s disease pathogenesis. Immun Ageing 2016,13:23. Doi: 10.1186/s12979-016-0078-8
• Cruz A, Pimentel L, Rodríguez-Alcalá LM, Fernandes T, Pintado M. Health benefits of edible mushrooms focused on Coriolus versicolor: A review. J Food Nutr Res 2016;4(12):773781. Doi: 12691/jfnr4122

2017

• Trovato A, Pennisi M, Crupi R, Di Paola R, Alario A, Modafferi S, Di Rosa G, Fernandes T, Signorile A, Maiolino L, Cuzzocrea S, Calabrese V. Neuroinflammation and mitochondrial dysfunction in the pathogenesis of Alzheimer’s Disease: modulation by Coriolus versicolor (Yun-Zhi) nutritional mushroom. J Neurol Neuromed 2017;2(1):19–28. Doi: 29245/2572.942X/2017/2.942X/2017/1.1088
• Ferrão J, Bell V, Calabrese V, Pimentel L, Pintado M, Fernandes TH. Impact of mushroom nutrition on microbiota and potential for preventative health. J Food Nutr Res 2017;5(4):226-233. Doi: 12691/jfnr-5-4-4

2018

• Ferreiro E, Pita IR, Mota SI, Valer J, Ferreira NR, Fernandes T, Calabrese V, Fontes-Ribeiro CA, Pereira FC, Rego AC. Coriolus versicolor biomass increases dendritic arborization of newly-generated neurons in mouse hippocampal dentate gyrus. Oncotarget 2018; 9(68):32929- 32942. Doi: 18632/oncotarget.25978

2020

• Scuto M, Di Mauro P, Ontario ML, Amato C, Modafferi S, Ciavardelli D, Trovato Salinaro A, Maiolino L, Calabrese V. Nutritional mushroom treatment in Meniere’s disease with Coriolus versicolor: A rationale for therapeutic intervention in neuroinflammation and antineurodegeneration. Int J Sci 2020;21:284. Doi: 3390/ijms21010284
• Ines Amara I, Scuto M, Zappalà A, Ontario ML, Petralia A, Abid-Essefi S, Maiolino L, Signorile A, Trovato Salinaro A, Calabrese V. Hericium erinaceus prevents DEHP-induced mitochondrial dysfunction and apoptosis in PC12 cells. Int J Mol Sci 2020;21:2138. Doi: 3390/ijms21062138
• Gincheva D, Gincheva V, Konova E. Effectf of combined therapy polyhexamethylene biguanide and Coriolus-MRL on human papilloma virus (HPV) cervical and vulvar-related lesions. Int J Med Device Adj Treatments 2020;3:e220 . Doi: 32113/ijmdat_20201_220

2021

• Cordaro M, Trovato Salinaro A, Siracusa R, D’Amico R, Impellizzeri D, Scuto M, Ontario ML, Cuzzocrea S, Di Paola R, Fusco R, Calabrese V. Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease Antioxidants 2021;10:1664. Doi: 3390/antiox10111664
• D’Amico R, Trovato Salinaro A, Fusco R, Cordaro M, ImpellizzeriD, Scuto M, Ontario ML, Lo Dico G, Cuzzocrea S,Di Paola R, Siracusa R, Calabrese V. Hericium erinaceus and Coriolus versicolor modulate molecular and biochemical changes after traumatic brain injury. Antioxidants 2021;10:898. Doi: 3390/antiox10060898
• Simonovsky K, Vancurikova Z. A TCM Perspective on Mushroom Nutrition: Hericium erinaceus and Trametes versicolor (synn. Coriolus versicolor) as a synergistic combination for nourishment of both brains. EJOM 2021;9(6).

2022

• Dimpfel W, Wiebe J, Gericke N. Central nervous system profiling of Hericium erinaceus biomass powder by an electropharmacogram using spectral field power in conscious freely moving rats. Clin J Mycol 2022;6.1;2. Doi: 54225/cjm.vol6.1.2010557
• Ferreiro E, Fernandes TH. Targeting neurogenesis with mushroom nutrition: A mini review. Clin J Mycol 2022;6.2. Doi: 54225/cjm.vol6.2.35294
• Calabrese V, Ontario M. Mushroom Nutrition in Neurodegenerative Diseases 2022. : (2022). Mushroom Nutrition in Neurodegenerative Diseases. Clin J Mycol 2022;6. Doi: 54225/cjm.vol6.3.71520
• Cordaro M, Modafferi S, D’Amico R, Fusco R, Genovese T, Peritore AF, Gugliandolo E, Crupi R, Interdonato L, Di Paola D, Impellizzeri D, Cuzzocrea S, Calabrese V, Di Paola R, Siracusa R. Natural compounds such as Hericium erinaceus and Coriolus versicolor modulate neuroinflammation, oxidative stress and lipoxin A4 expression in rotenone-induced Parkinson’s disease in mice. Biomedicines 2022;10:2505. Doi: 3390/biomedicines10102505
• Marika Cordaro, Sergio Modafferi, Ramona D’Amico, Roberta Fusco, Tiziana Genovese, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Livia Interdonato, Davide Di Paola, DanielaImpellizzeri, Salvatore Cuzzocrea , Vittorio Calabrese, Rosanna Di Paola and Rosalba Siracusa. Natural Compounds such as Hericium erinaceus and Coriolus versicolor Modulate Neuroinflammation, Oxidative Stress and Lipoxin A4 Expression in Rotenone-Induced Parkinson’s Disease in Mice. Doi: 3390/biomedicines10102505
• Daniela Impellizzeri , Roberta Fusco , Tiziana Genovese, Marika Cordaro, Ramona D’Amico, Angela Trovato Salinaro, Maria Laura Ontario, Sergio Modafferi, Salvatore Cuzzocrea, Rosanna Di Paola, Vittorio Calabrese and Rosalba Siracusa.Coriolus Versicolor Downregulates TLR4/NF-κB Signaling Cascade in Dinitrobenzenesulfonic Acid-Treated Mice: A Possible Mechanism for the Anti-Colitis Effect. Antioxidants 2022, 11, 406 .  Doi: 3390/antiox11020406

2023     

• Helena Araújo-Rodrigues, Manuela Amorim, Ana Sofia Salsinha, Sara Marçal, FreniK. Tavaria, João B. Relvas andManuela E. Pintado. Characterization of bioactive compounds in mushroom biomass of Coriolus versicolor, Hericium erinaceus and Pleurotus ostreatus species. Presented at the XXII FoodChem Congress, June 14-16, 2023 Belgrade, Serbia.https://www.mycologyresearch.com/articles/characterization-of-bioactive-compounds-in-mushroom-biomass-of-coriolus-versicolor-hericium-erinaceus-and-pleurotus-ostreatus-species

Certifications

Hericor-MRL biomass is produced and manufactured in accordance with both EU and UK organic standards. Finished products are manufactured under FSSC 22000 in Netherlands.